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The active ingredient of Tadagra is Tadalafil. It is used in the treatment of erectile dysfunction, benign prostatic hypertrophy and pulmonary arterial hypertension.  Tadalafil was introduced in the market after the introduction of Sildenafil and Vardenafil. In the year 2003, the Food and Drug Administration approved Tadalafil for sale in the United States as the third drug for treating erectile dysfunction in adults. 

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Details

Mechanism of Action-

Tadalafil is a Type 5 phosphodiesterase inhibitor. The phosphodiesterase type 5 (PDE5) inhibitors are responsible for causing vasodilation in the penis and lung by preventing the breakdown of cyclic guanosine monophosphate (cGMP).  The type-5 phosphodiesterase enzymes are enzyme that is found mainly in the penis and lung.  So, the action of the PDE inhibitors is exerted mainly in the penis and in the lung where it acts to reduce pulmonary vascular pressure.

Contraindications-

It is not recommended to take Tadalafil if someone is taking nitrate drugs for chest pain or cardiac problems. Nitrate drugs includes nitroglycerin, isosorbide dinitrate and isosorbide mononitrate, Sudden lowering of blood pressure can take place as a result of co ingestion of nitrate drugs along with Tadalafil.

Drug Interactions-

One should not use Tadagra with amyl nitrite, hydralazine, isosorbide, nitroglycerin and nitroprusside. Combination of these drugs causes lowering of blood pressure and cardiovascular problems. The effects of drug interactions are dizziness, lightheadedness, fainting, flushing, heart palpitations, and priapism. (Prolonged and painful erection of penis). One should also not use Tadalafil with boceprevir and telaprevir as the co-ingestion increases the level of Tadalafil in the blood and causes several adverse effects.

Storage-

It is advised to store Tadagra at 25 degrees centigrade and away from heat, moisture and direct sun light. It should not be kept in bathroom and should be kept out of reach of children.

Dosage-

There are different doses for different diseases which may be treated with Tadagra.

For Erectile Dysfunction

Initial dose of the drug is 10 mg before performing sexual intercourse.  Advanced dose of the drug is 20 mg before performing sexual intercourse.

For Benign Prostate Hyperplasia (BPH)

5 mg of the drug should be used every day.

For Pulmonary Arterial Hypertension

40 mg of the drug should be used every day.

Over dosage of Tadagra-

Kindly take emergency medical attention.

Missed Dosage of Tadagra-

Tadagra is taken only when it is needed. There is no dosing schedule.

Side Effects of Tadagra-

The common side effects of Tadagra are:

1) Feeling of Nausea during sexual activity.

2) Tingling sensation in chest, arm and leg.

3)  Feeling of pain and numbness in the body.

The serious side effects of Tadagra are:

1) Changes in Vision.

2) Irregular Heartbeat.

3) Chest Pain.

4) Feeling of light headedness.

5) Seizure.

Precautions-

Tadalafil is not recommended in patients who had myocardial infarction in the recent past, who are suffering from angina, uncontrolled arrthymias or hypotension.

Administration of Tadalafil to patients suffering from leukemia or anemia may cause prolonged erection of penis in them, a condition known as priapism.

There may be sudden hearing loss or vision loss in some people. Patients having non-arteritic anterior ischemic optic neuropathy (NAION) are at greater risk.

Patients should be very careful while taking antihypertensive along with Tadalafil as concomitant use may lower the blood pressure to a great extent.

Tadagra should not be taken more than 5 mg by patients who have a renal clearance rate of less than 30Ml/min.

Tadagra should not be consumed along with alcohol.